{"id":4082,"date":"2017-08-01T23:26:02","date_gmt":"2017-08-01T23:26:02","guid":{"rendered":"https:\/\/labsites.rochester.edu\/gsharma\/?page_id=4082"},"modified":"2017-10-14T11:51:40","modified_gmt":"2017-10-14T11:51:40","slug":"rnastructestim","status":"publish","type":"page","link":"https:\/\/labsites.rochester.edu\/gsharma\/research\/medbioinformatics\/rnastructestim\/","title":{"rendered":"RNA Structure Estimation from Multiple Homologs"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-1842 alignleft\" src=\"https:\/\/labsites.rochester.edu\/gsharma\/wp-content\/uploads\/2017\/05\/BioInfo-300x186.png\" alt=\"\" width=\"300\" height=\"186\" srcset=\"https:\/\/labsites.rochester.edu\/gsharma\/wp-content\/uploads\/2017\/05\/BioInfo-300x186.png 300w, https:\/\/labsites.rochester.edu\/gsharma\/wp-content\/uploads\/2017\/05\/BioInfo.png 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Nature encodes the functional structure of a (noncoding) RNA molecule as multiple alternative homologous sequences in different organisms. In our work, we seek to decode this common structure by exploiting this comparative information across the multiple homologs in combination with thermodynamic models for predicting secondary structure.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 14pt;\"><strong>Software<\/strong><\/span><\/p>\n<p>The tools developed in this work are distributed in open source format as part of the <a href=\"http:\/\/rna.urmc.rochester.edu\/RNAstructure.html\">RNA Structure package<\/a> from the Mathews lab.<\/p>\n<p><span style=\"font-size: 14pt;\"><strong>Selected Publications<\/strong><\/span><\/p>\n<div class=\"teachpress_pub_list\"><form name=\"tppublistform\" method=\"get\"><a name=\"tppubs\" id=\"tppubs\"><\/a><\/form><div class=\"teachpress_message_error\"><p>Sorry, no publications matched your criteria.<\/p><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nature encodes the functional structure of a (noncoding) RNA molecule as multiple alternative homologous sequences in different organisms. In our work, we seek to decode this common structure by exploiting this comparative information across the multiple homologs in combination with thermodynamic models for predicting secondary structure. &nbsp; &nbsp; Software The tools developed in this work [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":0,"parent":1732,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width.php","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-4082","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/Paivks-13Q","_links":{"self":[{"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/pages\/4082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/comments?post=4082"}],"version-history":[{"count":3,"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/pages\/4082\/revisions"}],"predecessor-version":[{"id":4592,"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/pages\/4082\/revisions\/4592"}],"up":[{"embeddable":true,"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/pages\/1732"}],"wp:attachment":[{"href":"https:\/\/labsites.rochester.edu\/gsharma\/wp-json\/wp\/v2\/media?parent=4082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}