{"id":532,"date":"2026-01-15T15:19:25","date_gmt":"2026-01-15T20:19:25","guid":{"rendered":"https:\/\/labsites.rochester.edu\/dfulab\/?page_id=532"},"modified":"2026-01-15T15:19:25","modified_gmt":"2026-01-15T20:19:25","slug":"publications","status":"publish","type":"page","link":"https:\/\/labsites.rochester.edu\/dfulab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div id=\"selectbar\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/dragony.fu.1\/bibliography\/public\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-size: 1rem;\">https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/dragony.fu.1\/bibliography\/public\/<\/span><\/a><\/div>\n<div><\/div>\n<div>\n<hr \/>\n<\/div>\n<div>\n<div>\n<ul>\n<li><span class=\"authors\"><strong>Berger KD<\/strong>, Puthenpeedikakkal AMK, Mathews DH, <strong>Fu D<\/strong>. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40158946\/\">Structural Impact of 3-methylcytosine Modification on the Anticodon Stem-loop of a Neuronally-enriched Arginine tRNA. <\/a><span class=\"source\">J Mol Biol<\/span>. <span class=\"pubdate\">2025 Aug 15;<\/span><span class=\"volume\">437<\/span><span class=\"issue\">(16)<\/span><span class=\"pages\">:169096<\/span>. <span class=\"doi\">doi: 10.1016\/j.jmb.2025.169096. <\/span><span class=\"pubstatus\">Epub 2025 Mar 29. <\/span><span class=\"pmid\">PubMed PMID: 40158946<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC12162224<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\">Efthymiou S, <strong>Leo CP, Deng C<\/strong>, Lin SJ, Maroofian R, Lin R, Karagoz I, <strong>Zhang K<\/strong>, Kaiyrzhanov R, Scardamaglia A, Owrang D, Turchetti V, Jahnke F, Huang K, Petree C, Derrick AV, Rees MI, Alvi JR, Sultan T, Li C, Jacquemont ML, Tran-Mau-Them F, Valenzuela-Palafoll M, Sidlow R, Yoon G, Morrow MM, Carere DA, O&#8217;Connor M, Fleischer J, Gerkes EH, Phornphutkul C, Isidor B, Rivier-Ringenbach C, Philippe C, Kurul SH, Soydemir D, Kara B, Sunnetci-Akkoyunlu D, Bothe V, Platzer K, Wieczorek D, Koch-Hogrebe M, Rahner N, Thuresson AC, Matsson H, Frykholm C, Bozdo\u011fan ST, Bisgin A, Chatron N, Lesca G, Cabet S, T\u00fcmer Z, Hjortsh\u00f8j TD, R\u00f8nde G, Marquardt T, Reunert J, Afzal E, Zamani M, Azizimalamiri R, Galehdari H, Nourbakhsh P, Chamanrou N, Chung SK, Suri M, Benke PJ, Zaki MS, Gleeson JG, Calame DG, Pehlivan D, Yilmaz HI, Gezdirici A, Rad A, Abumansour IS, Oprea G, Bereketo\u011flu MB, Banneau G, Julia S, Zeighami J, Ashoori S, Shariati G, Sedaghat A, Sabri A, Hamid M, Parvas S, Tajudin TA, Abdullah U, Baig SM, Chung WK, Glazunova OO, Sabine S, Cheema HA, Zifarelli G, Bauer P, Sidpra J, Mankad K, Vona B, Fry AE, Varshney GK, Houlden H, <strong>Fu D<\/strong>. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40245862\/\">Bi-allelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder. <\/a><span class=\"source\">Am J Hum Genet<\/span>. <span class=\"pubdate\">2025 May 1;<\/span><span class=\"volume\">112<\/span><span class=\"issue\">(5)<\/span><span class=\"pages\">:1117-1138<\/span>. <span class=\"doi\">doi: 10.1016\/j.ajhg.2025.03.015. <\/span><span class=\"pubstatus\">Epub 2025 Apr 16. <\/span><span class=\"pmid\">PubMed PMID: 40245862<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC12120178<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\"><strong>Zhang K<\/strong>, Manning AC, <strong>Lentini JM<\/strong>, Howard J, Dalwigk F, Maroofian R, Efthymiou S, Chan P, <strong>Eliseev SI, Yang Z<\/strong>, Chang H, Karimiani EG, Bakhshoodeh B, Houlden H, Kaiser SM, Lowe TM, <strong>Fu D<\/strong>. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39786990\/\">Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs. <\/a><span class=\"source\">Cell Rep<\/span>. <span class=\"pubdate\">2025 Jan 28;<\/span><span class=\"volume\">44<\/span><span class=\"issue\">(1)<\/span><span class=\"pages\">:115092<\/span>. <span class=\"doi\">doi: 10.1016\/j.celrep.2024.115092. <\/span><span class=\"pubstatus\">Epub 2025 Jan 8. <\/span><span class=\"pmid\">PubMed PMID: 39786990<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC11831618<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\"><strong>Zhang K<\/strong>, L\u00f6hner K, Lemmink HH, Boon M, <strong>Lentini JM, de Silva N, Fu D. <\/strong><\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39482881\/\">Epileptic encephalopathy linked to a DALRD3 missense variant that impairs tRNA modification. <\/a><span class=\"source\">HGG Adv<\/span>. <span class=\"pubdate\">2025 Jan 9;<\/span><span class=\"volume\">6<\/span><span class=\"issue\">(1)<\/span><span class=\"pages\">:100377<\/span>. <span class=\"doi\">doi: 10.1016\/j.xhgg.2024.100377. <\/span><span class=\"pubstatus\">Epub 2024 Oct 31. <\/span><span class=\"pmid\">PubMed PMID: 39482881<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC11615593<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\">Madhwani KR, Sayied S, Ogata CH, Hogan CA, <strong>Lentini JM<\/strong>, Mallik M, Dumouchel JL, Storkebaum E,<strong> Fu D<\/strong>, O&#8217;Connor-Giles KM. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39495910\/\">tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory. <\/a><span class=\"source\">Proc Natl Acad Sci U S A<\/span>. <span class=\"pubdate\">2024 Nov 12;<\/span><span class=\"volume\">121<\/span><span class=\"issue\">(46)<\/span><span class=\"pages\">:e2317864121<\/span>. <span class=\"doi\">doi: 10.1073\/pnas.2317864121. <\/span><span class=\"pubstatus\">Epub 2024 Nov 4. <\/span><span class=\"pmid\">PubMed PMID: 39495910<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC11572970<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\"><strong>Zhang K,<\/strong> Ciesla JH, Eldin P, Briant L, <strong>Lentini JM<\/strong>, <strong>Ramos J<\/strong>, Munger J, <strong>Fu D<\/strong>. <\/span><span class=\"title\">Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease. <\/span><span class=\"repository\">BioRxiv<\/span><span class=\"contenttype\"> [preprint]. <\/span><span class=\"displaydate\">2023 February. <\/span><span class=\"arXiv\">bioRxiv 2023.02.10.527147<\/span><span class=\"url\">Available from: https:\/\/doi.org\/10.1101\/2023.02.10.527147.<\/span><br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\">Hogan CA, Gratz SJ, Dumouchel JL, Thakur RS, Delgado A, <strong>Lentini JM<\/strong>, Madhwani KR, <strong>Fu D, O&#8217;Connor-Giles KM<\/strong>. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37642556\/\">Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function. <\/a><span class=\"source\">EMBO Rep<\/span>. <span class=\"pubdate\">2023 Oct 9;<\/span><span class=\"volume\">24<\/span><span class=\"issue\">(10)<\/span><span class=\"pages\">:e56808<\/span>. <span class=\"doi\">doi: 10.15252\/embr.202356808. <\/span><span class=\"pubstatus\">Epub 2023 Aug 29. <\/span><span class=\"pmid\">PubMed PMID: 37642556<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC10561368<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\">Longan ER, <strong>Ramos J, Fu D<\/strong>. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36733466\/\">ADATscan &#8211; A flexible tool for scanning exomes for wobble inosine-dependent codons reveals a neurological bias for genes enriched in such codons in humans and mice. <\/a><span class=\"source\">MicroPubl Biol<\/span>. <span class=\"pubdate\">2023;<\/span><span class=\"volume\">2023<\/span>. <span class=\"doi\">doi: 10.17912\/micropub.biology.000675. <\/span><span class=\"pubstatus\">eCollection 2023. <\/span><span class=\"pmid\">PubMed PMID: 36733466<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC9887483<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><strong><span class=\"authors\">Lentini JM, Bargabos R, Chen C, Fu D. <\/span><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35247384\/\" target=\"_blank\" rel=\"noopener\">Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs. <\/a><span class=\"source\">J Biol Chem<\/span>. <span class=\"pubdate\">2022 Apr;<\/span><span class=\"volume\">298<\/span><span class=\"issue\">(4)<\/span><span class=\"pages\">:101788<\/span>. <span class=\"doi\">doi: 10.1016\/j.jbc.2022.101788. <\/span><span class=\"pubstatus\">Epub 2022 Mar 3. <\/span><span class=\"pmid\">PubMed PMID: 35247384<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC8980813<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\">Broly M, Polevoda BV, Awayda KM, Tong N, <strong>Lentini J<\/strong>, Besnard T, Deb W, O&#8217;Rourke D, Baptista J, Ellard S, Almannai M, Hashem M, Abdulwahab F, Shamseldin H, Al-Tala S, Alkuraya FS, Leon A, van Loon RLE, Ferlini A, Sanchini M, Bigoni S, Ciorba A, van Bokhoven H, Iqbal Z, Al-Maawali A, Al-Murshedi F, Ganesh A, Al-Mamari W, Lim SC, Pais LS, Brown N, Riazuddin S, B\u00e9zieau S, <strong>Fu D<\/strong>, Isidor B, Cogn\u00e9 B, O&#8217;Connell MR. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35196516\/\" target=\"_blank\" rel=\"noopener\">THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder. <\/a><span class=\"source\">Am J Hum Genet<\/span>. <span class=\"pubdate\">2022 Apr 7;<\/span><span class=\"volume\">109<\/span><span class=\"issue\">(4)<\/span><span class=\"pages\">:587-600<\/span>. <span class=\"doi\">doi: 10.1016\/j.ajhg.2022.02.001. <\/span><span class=\"pubstatus\">Epub 2022 Feb 22. <\/span><span class=\"pmid\">PubMed PMID: 35196516<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC9069073<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"docsum-journal-citation full-journal-citation\"><strong>Ramos J, Fu D.<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34517952\/\" target=\"_blank\" rel=\"noopener\">Detection of tRNA-specific adenosine deaminase activity and wobble inosine modification in human cell lysates.<\/a> Methods Enzymol. 2021;658:311-334. doi: 10.1016\/bs.mie.2021.06.008. Epub 2021 Jul 24.<\/span><span class=\"citation-part\">PMID: <span class=\"docsum-pmid\">34517952.<\/span><\/span><br \/>\n<hr \/>\n<\/li>\n<li><strong><span class=\"authors\">Lentini JM, Fu D. <\/span><\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34085247\/\" target=\"_blank\" rel=\"noopener\">Monitoring the 5-Methoxycarbonylmethyl-2-Thiouridine (mcm5s2U) Modification Utilizing the Gamma-Toxin Endonuclease.<\/a> <span class=\"source\">Methods Mol Biol<\/span>. <span class=\"pubdate\">2021;<\/span><span class=\"volume\">2298<\/span><span class=\"pages\">:197-216<\/span>. <span class=\"doi\">doi: 10.1007\/978-1-0716-1374-0_13. <\/span><span class=\"pmid\">PubMed PMID: 34085247<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\">Kulkarni CA, Nadtochiy SM, Kennedy L, Zhang J, <strong>Chhim S,<\/strong> Alwaseem H, Murphy E, <strong>Fu D<\/strong>, Brookes PS.<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32795389\/\" target=\"_blank\" rel=\"noopener\">ALKBH7 mediates necrosis via rewiring of glyoxal metabolism. <\/a><span class=\"source\">Elife<\/span>. <span class=\"pubdate\">2020 Aug 14;<\/span><span class=\"volume\">9<\/span>. <span class=\"doi\">doi: 10.7554\/eLife.58573. <\/span><span class=\"pmid\">PubMed PMID: 32795389<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC7442491<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\"><strong>Ramos J, Proven M,<\/strong> Halvardson J, Hagelskamp F, Kuchinskaya E, <strong>Phelan B, Bell R<\/strong>, Kellner S, Feuk L, Thuresson AC, <strong>Fu D<\/strong>. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32763916\/\" target=\"_blank\" rel=\"noopener\">Identification and rescue of a tRNA wobble inosine deficiency causing intellectual disability disorder. <\/a><span class=\"source\">RNA<\/span>. <span class=\"pubdate\">2020 Aug 6;<\/span>. <span class=\"doi\">doi: 10.1261\/rna.076380.120. <\/span><span class=\"pubstatus\">[Epub ahead of print] <\/span><span class=\"pmid\">PubMed PMID: 32763916<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\"><strong>Lentini JM<\/strong>, Alsaif HS, Faqeih E, Alkuraya FS, <strong>Fu D<\/strong>. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32427860\/\" target=\"_blank\" rel=\"noopener\">DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification. <\/a><span class=\"source\">Nature Commun<\/span>. <span class=\"pubdate\">2020 May 19;<\/span><span class=\"volume\">11<\/span><span class=\"issue\">(1)<\/span><span class=\"pages\">:2510<\/span>. <span class=\"doi\">doi: 10.1038\/s41467-020-16321-6. <\/span><span class=\"pmid\">PubMed PMID: 32427860<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC7237682<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\">Hagelskamp F, Borland K, <strong>Ramos J<\/strong>, Hendrick AG,<strong> Fu D<\/strong>, Kellner S. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32083657\/\" target=\"_blank\" rel=\"noopener\">Broadly applicable oligonucleotide mass spectrometry for the analysis of RNA writers and erasers in vitro. <\/a><span class=\"source\">Nucleic Acids Res<\/span>. <span class=\"pubdate\">2020 Apr 17;<\/span><span class=\"volume\">48<\/span><span class=\"issue\">(7)<\/span><span class=\"pages\">:e41<\/span>. <span class=\"doi\">doi: 10.1093\/nar\/gkaa091. <\/span><span class=\"pmid\">PubMed PMID: 32083657<\/span><span class=\"pmcid\">; PubMed Central PMCID: PMC7144906<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li><span class=\"authors\"><strong>Zhang K, Lentini JM, Prevost CT<\/strong>, Hashem MO, Alkuraya FS, <strong>Fu D<\/strong>. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31898845\/\" target=\"_blank\" rel=\"noopener\">An intellectual disability-associated missense variant in TRMT1 impairs tRNA modification and reconstitution of enzymatic activity. <\/a><span class=\"source\">Hum Mutat<\/span>. <span class=\"pubdate\">2020 Jan 3;<\/span>. <span class=\"doi\">doi: 10.1002\/humu.23976. <\/span><span class=\"pubstatus\">[Epub ahead of print] <\/span><span class=\"pmid\">PubMed PMID: 31898845<\/span>.<br \/>\n<hr \/>\n<\/li>\n<li>Shaheen R, Mark P,<strong> Prevost CT<\/strong>, AlKindi A, Alhag A, Estwani F, Al-Sheddi T, Alobeid E, Alenazi MM, Ewida N, Ibrahim N, Hashem M, Abdulwahab F, Bryant EM, Spinelli E, Millichap J, Barnett SS, Kearney HM, Accogli A, Scala M, Capra V, Nigro V, <strong>Fu D<\/strong>, Alkuraya FS. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31301155\/\" target=\"_blank\" rel=\"noopener\">Biallelic variants in CTU2 cause DREAM-PL syndrome and impair thiolation of tRNA wobble U34. <\/a>Hum Mutat. 2019 Jul 13;. doi: 10.1002\/humu.23870. [Epub ahead of print] PubMed PMID: 31301155.<br \/>\n<hr \/>\n<\/li>\n<li><strong style=\"font-size: 1rem;\">Ramos J<\/strong><span style=\"font-size: 1rem;\">, Han L, <\/span><strong style=\"font-size: 1rem;\">Li Y<\/strong><span style=\"font-size: 1rem;\">, Hagelskamp F, Kellner SM, Alkuraya FS, Phizicky EM, <\/span><strong style=\"font-size: 1rem;\">Fu D<\/strong><span style=\"font-size: 1rem;\">. <\/span><a style=\"font-size: 1rem;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31263000\/\" target=\"_blank\" rel=\"noopener\">Formation of tRNA wobble inosine in humans is disrupted by a millennia-old mutation causing intellectual disability. <\/a><span style=\"font-size: 1rem;\">Mol Cell Biol. 2019 Jul 1;. doi: 10.1128\/MCB.00203-19. [Epub ahead of print] PubMed PMID: 31263000.<\/span><br \/>\n<hr \/>\n<\/li>\n<li><strong style=\"font-size: 1rem;\">Ramos J, Fu D<\/strong><span style=\"font-size: 1rem;\">. <\/span><a style=\"font-size: 1rem;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30529455\/\" target=\"_blank\" rel=\"noopener\">The emerging impact of tRNA modifications in the brain and nervous system. <\/a><span style=\"font-size: 1rem;\">Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):412-428. doi: 10.1016\/j.bbagrm.2018.11.007. Epub 2018 Dec 5. Review. PubMed PMID: 30529455.<\/span><\/li>\n<li><span style=\"font-size: 1rem;\">Gu C, <\/span><strong style=\"font-size: 1rem;\">Ramos J<\/strong><span style=\"font-size: 1rem;\">, Begley U, Dedon PC, <\/span><strong style=\"font-size: 1rem;\">Fu D<\/strong><span style=\"font-size: 1rem;\">, Begley TJ. <\/span><a style=\"font-size: 1rem;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30009260\/\" target=\"_blank\" rel=\"noopener\">Phosphorylation of human TRM9L integrates multiple stress-signaling pathways for tumor growth suppression. <\/a><span style=\"font-size: 1rem;\">Sci Adv. 2018 Jul;4(7):eaas9184. doi: 10.1126\/sciadv.aas9184. eCollection 2018 Jul. PubMed PMID: 30009260; PubMed Central PMCID: PMC6040840.<\/span><br \/>\n<hr \/>\n<\/li>\n<li><strong style=\"font-size: 1rem;\">Lentini JM, Ramos J, Fu D<\/strong><span style=\"font-size: 1rem;\">. <\/span><a style=\"font-size: 1rem;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29440318\/\" target=\"_blank\" rel=\"noopener\">Monitoring the 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification in eukaryotic tRNAs via the \u03b3-toxin endonuclease. <\/a><span style=\"font-size: 1rem;\">RNA. 2018 May;24(5):749-758. doi: 10.1261\/rna.065581.118. Epub 2018 Feb 13. PubMed PMID: 29440318; PubMed Central PMCID: PMC5900570.<\/span><br \/>\n<hr \/>\n<\/li>\n<li><span style=\"font-size: 1rem;\">Padgett LR, <\/span><strong style=\"font-size: 1rem;\">Lentini JM<\/strong><span style=\"font-size: 1rem;\">, Holmes MJ, Stilger KL, <\/span><strong style=\"font-size: 1rem;\">Fu D,<\/strong><span style=\"font-size: 1rem;\"> Sullivan WJ Jr. <\/span><a style=\"font-size: 1rem;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29293520\/\" target=\"_blank\" rel=\"noopener\">Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii. <\/a><span style=\"font-size: 1rem;\">PLoS One. 2018;13(1):e0189688. doi: 10.1371\/journal.pone.0189688. eCollection 2018. PubMed PMID: 29293520; PubMed Central PMCID: PMC5749711.<\/span><br \/>\n<hr \/>\n<\/li>\n<li><strong style=\"font-size: 1rem;\">Dewe JM, Fuller BL, Lentini JM<\/strong><span style=\"font-size: 1rem;\">, Kellner SM, <\/span><strong style=\"font-size: 1rem;\">Fu D<\/strong><span style=\"font-size: 1rem;\">. <\/span><a style=\"font-size: 1rem;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28784718\/\" target=\"_blank\" rel=\"noopener\">TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival. <\/a><span style=\"font-size: 1rem;\">Mol Cell Biol. 2017 Nov 1;37(21). doi: 10.1128\/MCB.00214-17. Print 2017 Nov 1. PubMed PMID: 28784718; PubMed Central PMCID: PMC5640816.<\/span><br \/>\n<hr \/>\n<\/li>\n<li><span style=\"font-size: 1rem;\">Jordan JJ, <\/span><strong style=\"font-size: 1rem;\">Chhim S<\/strong><span style=\"font-size: 1rem;\">, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, <\/span><strong style=\"font-size: 1rem;\">Fu D<\/strong><span style=\"font-size: 1rem;\">. <\/span><a style=\"font-size: 1rem;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28726787\/\" target=\"_blank\" rel=\"noopener\">ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. <\/a><span style=\"font-size: 1rem;\">Cell Death Dis. 2017 Jul 20;8(7):e2947. doi: 10.1038\/cddis.2017.343. PubMed PMID: 28726787; PubMed Central PMCID: PMC5550884.<\/span><br \/>\n<hr \/>\n<\/li>\n<li><span style=\"font-size: 1rem;\">Nadtochiy SM, Schafer X, <\/span><strong style=\"font-size: 1rem;\">Fu D<\/strong><span style=\"font-size: 1rem;\">, Nehrke K, Munger J, Brookes PS. <\/span><a style=\"font-size: 1rem;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27510037\/\" target=\"_blank\" rel=\"noopener\">Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling. <\/a><span style=\"font-size: 1rem;\">J Biol Chem. 2016 Sep 16;291(38):20188-97. doi: 10.1074\/jbc.M116.738799. Epub 2016 Aug 10. PubMed PMID: 27510037; PubMed Central PMCID: PMC5025701.<\/span>\n<div>\n<div>\n<hr \/>\n<\/div>\n<\/div>\n<p><strong><span style=\"text-decoration: underline;\">Postdoctoral<\/span><\/strong><\/li>\n<\/ul>\n<\/div>\n<ul id=\"public-view\">\n<li>\n<div>\n<div><strong>Fu D<\/strong>, Samson LD, H\u00fcbscher U, van Loon B. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26408825\/\">The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants. <\/a>DNA Repair (Amst).2015 Nov;35:13-8. doi: 10.1016\/j.dnarep.2015.09.008. Epub 2015 Sep 14. PubMed PMID: 26408825; PubMed Central PMCID: PMC5206904.<\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<div><strong>Fu D<\/strong>, Jordan JJ, Samson LD. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23666923\/\">Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis.<\/a>Genes Dev. 2013 May 15;27(10):1089-100. doi: 10.1101\/gad.215533.113. Epub 2013 May 10. PubMed PMID: 23666923; PubMed Central PMCID: PMC3672644.<\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<div><strong>Fu D<\/strong>, Calvo JA, Samson LD. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22237395\/\">Balancing repair and tolerance of DNA damage caused by alkylating agents. <\/a>Nat Rev Cancer.2012 Jan 12;12(2):104-20. doi: 10.1038\/nrc3185. Review. PubMed PMID: 22237395; PubMed Central PMCID: PMC3586545.<\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<div><strong>Fu D<\/strong>, Samson LD. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22079122\/\">Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG\/MPG glycosylase. <\/a>DNA Repair (Amst). 2012 Jan 2;11(1):46-52. doi: 10.1016\/j.dnarep.2011.10.004. Epub 2011 Nov 11. PubMed PMID: 22079122; PubMed Central PMCID: PMC3253959.<\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<div><strong>Fu D<\/strong>, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20308323\/\">Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. <\/a>Mol Cell Biol. 2010 May;30(10):2449-59. doi: 10.1128\/MCB.01604-09. Epub 2010 Mar 22. PubMed PMID: 20308323; PubMed Central PMCID: PMC2863699.<\/div>\n<\/div>\n<div>\n<hr \/>\n<\/div>\n<p><span style=\"text-decoration: underline;\"><strong>Graduate<\/strong><\/span><\/li>\n<li>\n<div>\n<div>Errington TM, <strong>Fu D<\/strong>, Wong JM, Collins K. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18710936\/\">Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference. <\/a>Mol Cell Biol. 2008 Oct;28(20):6510-20. doi: 10.1128\/MCB.00777-08. Epub 2008 Aug 18. PubMed PMID: 18710936; PubMed Central PMCID: PMC2577424.<\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<div><strong>Fu D<\/strong>, Collins K. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18082603\/\">Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. <\/a>Mol Cell. 2007 Dec 14;28(5):773-85. doi: 10.1016\/j.molcel.2007.09.023. PubMed PMID: 18082603; PubMed Central PMCID: PMC2917595.<\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<div><strong>Fu D<\/strong>, Collins K. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16481465\/\">Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association. <\/a>Genes Dev. 2006 Mar 1;20(5):531-6. doi: 10.1101\/gad.1390306. Epub 2006 Feb 15. PubMed PMID: 16481465; PubMed Central PMCID: PMC1410806.<\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<div><strong>Fu D<\/strong>, Collins K. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12769858\/\">Distinct biogenesis pathways for human telomerase RNA and H\/ACA small nucleolar RNAs. <\/a>Mol Cell. 2003 May;11(5):1361-72. PubMed PMID: 12769858.<\/div>\n<div>\n<hr \/>\n<\/div>\n<\/div>\n<p><strong><span style=\"text-decoration: underline;\">Undergraduate and Post-Baccalaureate<\/span><\/strong><\/li>\n<li>\n<div>\n<div>Xiao H, Sandaltzopoulos R, Wang HM, Hamiche A, Ranallo R, Lee KM, <strong>Fu D<\/strong>, Wu C. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11583616\/\">Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions. <\/a>Mol Cell. 2001 Sep;8(3):531-43. PubMed PMID: 11583616.<\/div>\n<\/div>\n<\/li>\n<li>\n<div>\n<div>Payne WE, Kaiser CA, Bevis BJ, Soderholm J, <strong>Fu D<\/strong>, Sears IB, Glick BS. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10923020\/\">Isolation of Pichia pastoris genes involved in ER-to-Golgi transport. <\/a>Yeast. 2000 Aug;16(11):979-93. doi: 10.1002\/1097-0061(200008)16:11&lt;979::AID-YEA594&gt;3.0.CO;2-C. PubMed PMID: 10923020.<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/dragony.fu.1\/bibliography\/public\/ Berger KD, Puthenpeedikakkal AMK, Mathews DH, Fu D. Structural Impact of 3-methylcytosine Modification on the Anticodon Stem-loop of a Neuronally-enriched Arginine tRNA. J Mol Biol. 2025 Aug 15;437(16):169096. doi:&hellip;<\/p>\n","protected":false},"author":72,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-532","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publications - DFU Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/labsites.rochester.edu\/dfulab\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - DFU Lab\" \/>\n<meta property=\"og:description\" content=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/dragony.fu.1\/bibliography\/public\/ Berger KD, Puthenpeedikakkal AMK, Mathews DH, Fu D. Structural Impact of 3-methylcytosine Modification on the Anticodon Stem-loop of a Neuronally-enriched Arginine tRNA. 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